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Erectile dysfunction (ED) is the inability of a man to achieve or maintain an erection sufficient for his sexual needs or the needs of his partner. Erectile dysfunction is sometimes called as “impotence”.
An external vacuum pump will produce an engorged penis with success approaching 90%; a penis ring will maintain this state, although it should be removed after not more than 30 minutes. The erection is not as rigid or hard as a natural erection; drugs or injections, when they work, may be preferable. Various studies show the degree of satisfaction of users and their partners to be vary variable, even when drugs and injections do not work; in one study, about 20% of men who tried a (high-priced) pump decided to proceed to purchase one. Other studies show higher percentages of satisfied users.
A study presented at the same AUA meeting found that unpadded seats reduce penile blood flow more than padded seats. The width of the padded seats wasn't a factor.
Tadalafil can cause hypotension (abnormally low blood pressure, which can lead to fainting and even shock) when given to patients who are taking nitrates. Patients taking nitrates daily, even patients taking nitrates only once a day, should not take tadalafil. Most commonly used nitrates are medications to relieve angina (chest pain due to insufficient blood supply to heart muscle because of narrowing of the coronary arteries). These include nitroglycerine tablets, patches, ointments, sprays, pastes, and isosorbide dinitrate and isosorbide mononitrate. Other nitrates such as amyl nitrate and butyl nitrate are found in some recreational drugs called "poppers".
The cardiac effects associated with sildenafil have been studied extensively. Sildenafil is absolutely contraindicated in patients taking nitrates such as nitroglycerin or isosorbide. This is because sildenafil, like the other PDE-5 inhibitor medications, can potentiate the vasodilatory effects of the nitrate-based medication, resulting in an exaggerated vasodilatory effect that is potentially dangerous. Patients with serious cardiac disease, with exertional angina, or taking multiple antihypertensive medications are advised to seek the advice of a cardiologist before beginning therapy with sildenafil. A number of studies examining the cardiac effects of sildenafil have conclusively shown that no adverse consequences exist under normal circumstances.
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PSA testing got a major lift from an endorsement by the American Cancer Society which has a history of overselling the value of early detection and advising the public to seek tests before their safety and efficacy has been established. Medical organizations like the American College of Physicians and the U.S. Preventive Services Task Force that carefully search the scientific evidence before making screening recommendations have refused to endorse the PSA test. By the time the American Cancer Society tempered its endorsement in 1997, the test had already worked its way into standard medical practice, and one survey showed that half the men over age 65 reported having had a PSA. Not many men, even if fully informed, can walk away from a cancer diagnosis and choose the watchful waiting option that should be offered. Worse, some men dont even know theyve had a PSA. It is often thrown in with usual blood work during a routine physical.
Some evidence suggests that smaller penis size is associated with erectile dysfunction.
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Stay positive. Don't talk about blame; instead, talk about what you and your partner want and need, and how to achieve it.
Dr. Bartolome R. Celli, chief of pulmonary care at St. Elizabeth's Medical Center in Boston, applauded the Dutch study but called for more research.
Metabolism (breakdown) of sildenafil is slowed by aging, liver and kidney dysfunction, and concurrent use of certain medications (such as erythromycin--an antibiotic, and protease inhibitors, for HIV). Slowed breakdown allows sildenafil to accumulate in the body and potentially may increase the risk of side effects. Therefore in men over 65, in men with substantial kidney and liver disease, and in men who also are taking protease inhibitors, the doctor will initiate sildenafil at a lower dose (25 mg) to avoid accumulation of sildenafil in the body. A protease inhibitor ritonavir (Norvir) is especially potent in increasing the accumulation of sildenafil, thus men who are taking Norvir should not take sildenafil doses higher than 25 mg and at a frequency of no greater than once in 48 hours.
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This oral agent has been available for many years. It has both a central and a peripheral effect. Its efficacy has been questioned because even in properly conducted, well-controlled studies, yohimbine is only slightly better than placebo. A renewed interest in this agent has occurred, particularly when combined with sildenafil or some of the other oral agents.
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